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KMID : 0376219870240020155
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Chonnam Medical Journal
1987 Volume.24 No. 2 p.155 ~ p.164
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The NK Cell Activity of Normal Persons Against K-562 Cells
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Abstract
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The urinary bladder is innervated by the pelvic nerve from the sacral parasympathetic outflow and the hypogastric nerve from the lumbar sympathetic outflow. However, the physiological role of the sympathetics was not clearly elucidated, because micturition reflex was abolished by severing the pelvic nerve, whereas the reflex was not affected by the section of the hypogastric nerve. Considering that the function of the bladder is the storage of urine and its periodic evacuation by the emptying reflex, there is a possibility that the sympathetic innervations may participate in the storage of urine for the periodic evacuation. The present experiments were undertaken to explore the role of the sympathetic innervations to the urinary bladder and distribution of different noradrenergic receptors to the muscles.
1) Stimulation of the hypogastric nerve or the administration of noradrena￢line produced a predominant increase of the intravesical pressure which was immediately followed by the decrease. The former response was mainly ori￢ginated from the contraction of the trigone muscle and the latter response from the relaxation of the detrusor muscle.
2) Contraction of the trigone by the stimulation of the hypogastric nerve was decreased by the pretreatment with phenoxybenzamine, and relaxation of the detrusor by the nerve stimulation was abolished by propranolol. Contraction of the trigone by the intravenous noradrenaline was abolished. by phenoxy￢benzamine and relaxation of the detrusor by the drug was. abolished by propr- anolol. The trigone responded with contraction to phenylephrine and the detrusor responded with relaxation to isoproterenol. The former response was abolished by phenoxybenzamine and the latter one by propranolol.
3) The trigone muscle strip responded with contraction to noradrenaline, and the response was abolished in presence of phenoxybenzamine and was reversed to relaxation which was abolished in presence of propranolol.
4) In most cases, detrusor muscle strip from the fundus responded with relaxation to noradrenaline, and the response was abolished in presence of propranolol and was reversed to contraction which was abolished in presence of phenoxybenzamine.
5) The dorsal detrusor muscle strip adjacent to the trigone always responded with contraction to noradrenaline, and the response was abolished in presence of phenoxybenzamine and was reversed to relaxation which was abolished in presence of propranolol.
These results suggest that the hypogastric nerve to the urinary bladder may play a role of urine storage prior to the periodic evacuation by the micturition reflex, through the contraction of the trigone adjacent to the bladder neck and the relaxation of the detrusor, and that the trigone ´and the detrusor muscles contain both a-and ,B-noradrenergic receptors, however, the a-receptor is predominant in the trigone and the n-receptor in the detrusor. But exceptionally the detrusor muscle adjacent to the trigone contains predominantly a-receptors.
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